Amiloride

Common Use

Frumil is a combination diuretic—in simple terms, a “water pill” that helps the body get rid of excess fluid. It contains two active ingredients that work together: amiloride (a potassium-sparing diuretic) and furosemide (a loop diuretic). Furosemide helps the kidneys remove excess water and salt from the body, while amiloride helps prevent the loss of too much potassium, which is an important mineral for heart and muscle function.

Frumil is used to treat several conditions where the body retains too much fluid:

High blood pressure (hypertension) – by reducing excess fluid, it helps lower blood pressure and reduces the workload on the heart

Congestive heart failure – a condition where the heart does not pump blood effectively, leading to fluid buildup in the lungs, legs, and other tissues

Edematous syndrome of various origins – swelling caused by fluid retention in conditions such as:

Chronic heart failure

Nephrotic syndrome – a kidney disorder that causes the body to excrete too much protein and retain fluid

Cirrhosis of the liver – scarring of the liver that can lead to fluid buildup in the abdomen (ascites) and legs

Dosage and Direction

If you are being treated for high blood pressure, it is important to understand that Frumil does not cure hypertension—it helps keep it under control. This means you will need to take it consistently, often for several weeks or longer, to maintain the benefits. Even if you feel well, do not stop taking it without speaking to your doctor first.

Take Frumil exactly as prescribed by your doctor, usually once daily in the morning to avoid having to urinate during the night.

Precautions

Before taking Frumil, let your doctor know if you have:

Diabetes – because diuretics can affect blood sugar levels

Kidney disease or liver disease

A history of drug allergies

While taking Frumil, be mindful of the following:

Avoid large amounts of foods high in potassium, such as bananas, baked potatoes, cantaloupe, avocado, raisins, and cooked spinach. Because Frumil contains a potassium-sparing diuretic, eating too many high-potassium foods can cause potassium levels to become too high.

Alcohol may increase the effects of this medication and some of its side effects, such as dizziness. It is best to limit or avoid alcohol while taking Frumil.

Do not stand up too quickly from a lying or sitting position. Sit for a few minutes before rising to avoid feeling dizzy or lightheaded.

Frumil helps the body retain potassium, so there is generally no need to use salt substitutes (which often contain potassium) unless your doctor advises otherwise.

If you are pregnant or planning to become pregnant, inform your doctor before taking this medication.

Contraindications

Frumil should not be used in patients with:

Hypersensitivity (allergy) to amiloride, furosemide, or any other ingredients in the medication

Hyperpotassemia (high potassium levels in the blood)

Severe kidney disorders (such as anuria, where the body stops producing urine)

Hepatic coma (a severe complication of liver disease affecting brain function)

Possible Side Effects

Common side effects of Frumil may include:

Dizziness

Vision changes

Dehydration (dry mouth) or thirst

Nausea and vomiting

Headache

Hyperpotassemia (high potassium levels) – symptoms may include muscle weakness, fatigue, or irregular heartbeat

Seek medical attention if you experience any of the following:

Muscle cramps

Irregular heartbeat

Tingling in the hands or feet

Unusual fatigue or weakness

Difficulty breathing

Difficulty urinating

Drug Interactions

Frumil may interact with a number of other medications. It is important to tell your doctor about all medications you are taking, including:

ACE inhibitors (such as lisinopril, ramipril) – used for high blood pressure and heart failure

Barbiturates (such as phenobarbital) – used for seizures or anxiety

Cholestyramine – used to lower cholesterol

Corticosteroids (such as prednisone) – used for inflammation

Insulin and other diabetes medications – diuretics can affect blood sugar levels

Cyclosporine – used after organ transplants

Muscle relaxants such as tubocurarine

Nonsteroidal anti-inflammatory drugs (NSAIDs) – such as ibuprofen or naproxen, which can reduce the effectiveness of diuretics

Other high blood pressure medications – combining them may cause blood pressure to drop too low

Missed Dose

If you miss a dose, take it as soon as you remember—unless it is almost time for your next dose. If that is the case, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Overdose

If you think you have taken too much Frumil, seek emergency medical attention immediately. There are no specific signs of overdose for this medication other than dehydration, but taking too much can cause excessive fluid loss, low blood pressure, and electrolyte imbalances.

Storage

Store Frumil at room temperature between 15–30°C (59–86°F). Keep it away from moisture and direct sunlight. Always keep the medication out of reach of children.

Disclaimer

We provide only general information about medications, which does not cover all directions, possible drug interactions, or precautions. Information on this site cannot be used for self-treatment or self-diagnosis. Any specific instructions for a particular patient should be agreed upon with your healthcare adviser or the doctor in charge of your case. We disclaim reliability of this information and any mistakes it may contain. We are not responsible for any direct, indirect, special, or other indirect damage as a result of any use of the information on this site, nor for the consequences of self-treatment.

About Our Service Cydoctors.com is an online pharmacy based right here in Cyprus. We understand that managing conditions like high blood pressure, heart failure, or fluid retention requires consistent, reliable access to your medication—so we’ve made our service straightforward, dependable, and built with your convenience in mind. Because we’re local to the island, we can arrange delivery in the shortest possible time. For our customers in Nicosia, Limassol, and Larnaca, we’re pleased to offer overnight delivery, so your Frumil can be with you by the next day, helping you keep that excess fluid under control and your blood pressure steady without any fuss.